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KMID : 0376419900140020071
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Chonbuk University Medical Journal
1990 Volume.14 No. 2 p.71 ~ p.79
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Effect fo Ru24213 on the cardiovascularsystem in anesthetized cat
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Kwak Yong-Geun
Oh Nam-Hyu
Kim Yong-Ki
Chae Soo-Wan
Cho Kyu-Park
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Abstract
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This study was purposed to evaluate the cardiovascular effect of RU24213 and the interaction betweenDA1, and DA2 activity in anesthetzed cat. The results obtained were as follows : 1. Intravenous or intraventricular RU24213 elicited dose-related hypotension and bradycardia.2. The hypotensive effect of intravenous RU24313 was blocked not by intravenous SCH23390 but by intravenous sulpiride, and the bradycardiac effect of intravenous RU24313 was blocked by intravenous SCH23390 or intravenous sulpiride. 3. The cardiovascular effect of intravenous RU24313 was blocked by intravenous phenoxybenzamine, propranolol, hexamethonium or atropine, " and bilateral vagotomy did not inhibit the hypotensive effect of intravenous RU24313 but inhibited bradycardiac effect of the drug. 4. The hypotensive and bradycardiac effects of intravenous RU24213 were inhibited by pretreatment with SKF38393. From the above results, it is suggested that hypotensive effect of RU24313 was developed via central and peripheral dopamine receptors, while bradycardiac effect of the drug´ was related to the peripheral and central sympathetic and parasympathetic nervous system, and unlike the action in behavior, activation of DA, receptor inhibits the action of DA2 agonist in cardiovascular system of cat.
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KEYWORD
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Ru24213, dopamine D₁, dopamine D₂receptor, cardiovascular system, cat
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